Phosphorylation at Ser<sup>724</sup> of the ER stress sensor IRE1&#945; governs its activation state and limits ER stress-induced hepatosteatosis.

Li, Yang; Huang, Shijia; Wang, Jingsi; Dai, Jianli; Cai, Jie; Yan, Shuai; Huang, Zhiliang; He, Shengqi; Wang, Ping; Liu, Jianmiao; Liu, Yong

Phosphorylation at Ser⁷²⁴ of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.

Li, Yang; Huang, Shijia; Wang, Jingsi; Dai, Jianli; Cai, Jie; Yan, Shuai; Huang, Zhiliang; He, Shengqi; Wang, Ping; Liu, Jianmiao; Liu, Yong.

Afiliación

Li Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Huang S; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Wang J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Dai J; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Cai J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Yan S; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huang Z; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
He S; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Wang P; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
Liu J; Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China.
Liu Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China. Electronic address: liuyong31279@whu.edu.cn.

J Biol Chem ; 298(6): 101997, 2022 06.

Article en En | MEDLINE | ID: mdl-35500653

Asunto(s)

Estrés del Retículo Endoplásmico; Endorribonucleasas; Proteínas Serina-Treonina Quinasas; Animales; Estrés del Retículo Endoplásmico/genética; Endorribonucleasas/genética; Endorribonucleasas/metabolismo; Activación Enzimática; Hígado Graso/genética; Fibroblastos/metabolismo; Ratones; Mutación; Fosforilación; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Transducción de Señal/genética; Proteína 1 de Unión a la X-Box/genética; Proteína 1 de Unión a la X-Box/metabolismo

Palabras clave

ER stress; IRE1α; RIDD; Xbp1; autophosphorylation; hepatic steatosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Endorribonucleasas / Estrés del Retículo Endoplásmico Límite: Animals Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article País de afiliación: China

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