In vitro and in vivo evaluation of DC-targeting PLGA nanoparticles encapsulating heparanase CD4<sup>+</sup> and CD8<sup>+</sup> T-cell epitopes for cancer immunotherapy.

Tang, Xu-Dong; Lü, Kui-Lin; Yu, Jin; Du, Han-Jian; Fan, Chao-Qiang; Chen, Lei

In vitro and in vivo evaluation of DC-targeting PLGA nanoparticles encapsulating heparanase CD4⁺ and CD8⁺ T-cell epitopes for cancer immunotherapy.

Tang, Xu-Dong; Lü, Kui-Lin; Yu, Jin; Du, Han-Jian; Fan, Chao-Qiang; Chen, Lei.

Afiliación

Tang XD; Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.
Lü KL; Department of Pediatrics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.
Yu J; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.
Du HJ; Department of Neurosurgery, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, 400030, China.
Fan CQ; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China. fcqxhkwjs@126.com.
Chen L; Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China. chenlei1977603@126.com.

Cancer Immunol Immunother ; 71(12): 2969-2983, 2022 Dec.

Article en En | MEDLINE | ID: mdl-35546204

Asunto(s)

Nanopartículas; Neoplasias; Humanos; Epítopos de Linfocito T/metabolismo; Ácido Poliglicólico/química; Ácido Poliglicólico/metabolismo; Receptor Toll-Like 3; Copolímero de Ácido Poliláctico-Ácido Poliglicólico/metabolismo; Ácido Láctico/química; Ácido Láctico/metabolismo; Ligandos; Células Dendríticas; Inmunoterapia/métodos; Linfocitos T CD8-positivos; Interleucina-12/metabolismo; Péptidos/metabolismo; Linfocitos T CD4-Positivos; Polietilenglicoles

Palabras clave

Dendritic cells; Heparanase; Nanoparticles; Targeting; Tumor immunotherapy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Immunol Immunother Asunto de la revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China

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