Asymmetric Radical Cyclization of Alkenes by Stereospecific Homolytic Substitution of Sulfinamides.

Chen, Yasu; Wu, Xinxin; Yang, Shan; Zhu, Chen

Chen, Yasu; Wu, Xinxin; Yang, Shan; Zhu, Chen.

Afiliación

Chen Y; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.
Wu X; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.
Yang S; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.
Zhu C; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.

Angew Chem Int Ed Engl ; 61(29): e202201027, 2022 07 18.

Article en En | MEDLINE | ID: mdl-35561057

ABSTRACT

ABSTRACT

We report a novel asymmetric radical cyclization of alkenes via stereospecific homolytic substitution of sulfinamides. This reaction produces a variety of cyclic sulfinamides with excellent stereocontrol. The protocol features broad functional group tolerance, high product diversity, and easy accessibility to feedstocks, and outlines a new pathway for the synthesis of chiral cyclic sulfinamides.

Asunto(s)

Alquenos; Ciclización; Estructura Molecular; Estereoisomerismo

Palabras clave

Asymmetric Synthesis; Cyclization; Homolytic Substitution; Radical Reactions; Sulfinamide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alquenos Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: China

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