Working memory and reward increase the accuracy of animal location encoding in the medial prefrontal cortex.
Cereb Cortex
; 33(5): 2245-2259, 2023 02 20.
Article
en En
| MEDLINE
| ID: mdl-35584788
ABSTRACT
The ability to perceive spatial environments and locate oneself during navigation is crucial for the survival of animals. Mounting evidence suggests a role of the medial prefrontal cortex (mPFC) in spatially related behaviors. However, the properties of mPFC spatial encoding and how it is influenced by animal behavior are poorly defined. Here, we train the mice to perform 3 tasks differing in working memory and reward-seeking a delayed non-match to place (DNMTP) task, a passive alternation (PA) task, and a free-running task. Single-unit recording in the mPFC shows that although individual mPFC neurons exhibit spatially selective firing, they do not reliably represent the animal location. The population activity of mPFC neurons predicts the animal location. Notably, the population coding of animal locations by the mPFC is modulated by animal behavior in that the coding accuracy is higher in tasks involved in working memory and reward-seeking. This study reveals an approach whereby the mPFC encodes spatial positions and the behavioral variables affecting it.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Corteza Prefrontal
/
Memoria a Corto Plazo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cereb Cortex
Asunto de la revista:
CEREBRO
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos