Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

Loveland, Anna B; Svidritskiy, Egor; Susorov, Denis; Lee, Soojin; Park, Alexander; Zvornicanin, Sarah; Demo, Gabriel; Gao, Fen-Biao; Korostelev, Andrei A

Loveland, Anna B; Svidritskiy, Egor; Susorov, Denis; Lee, Soojin; Park, Alexander; Zvornicanin, Sarah; Demo, Gabriel; Gao, Fen-Biao; Korostelev, Andrei A.

Afiliación

Loveland AB; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Svidritskiy E; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Susorov D; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Lee S; Department of Neurology, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Park A; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Zvornicanin S; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Demo G; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Gao FB; Central European Institute of Technology, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic.
Korostelev AA; Department of Neurology, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA. Fen-Biao.Gao@umassmed.edu.

Nat Commun ; 13(1): 2776, 2022 05 19.

Article en En | MEDLINE | ID: mdl-35589706

Asunto(s)

Esclerosis Amiotrófica Lateral; Demencia Frontotemporal; Esclerosis Amiotrófica Lateral/genética; Esclerosis Amiotrófica Lateral/metabolismo; Proteína C9orf72/genética; Proteína C9orf72/metabolismo; Microscopía por Crioelectrón; Dipéptidos/metabolismo; Demencia Frontotemporal/genética; Demencia Frontotemporal/metabolismo; Humanos; Proteínas/genética; Proteínas/metabolismo; Ribosomas/metabolismo; Transferasas

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Demencia Frontotemporal / Esclerosis Amiotrófica Lateral Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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