Dysregulation of the Scribble/YAP/ß-catenin axis sustains the fibroinflammatory response in a PKHD1<sup>-/-</sup> mouse model of congenital hepatic fibrosis.

Fabris, Luca; Milani, Chiara; Fiorotto, Romina; Mariotti, Valeria; Kaffe, Eleanna; Seller, Barbara; Sonzogni, Aurelio; Strazzabosco, Mario; Cadamuro, Massimiliano

Dysregulation of the Scribble/YAP/ß-catenin axis sustains the fibroinflammatory response in a PKHD1^-/- mouse model of congenital hepatic fibrosis.

Fabris, Luca; Milani, Chiara; Fiorotto, Romina; Mariotti, Valeria; Kaffe, Eleanna; Seller, Barbara; Sonzogni, Aurelio; Strazzabosco, Mario; Cadamuro, Massimiliano.

Afiliación

Fabris L; Department of Molecular Medicine (DMM), University of Padova, Padova, Italy.
Milani C; International Center for Digestive Health (ICDH), University of Milan-Bicocca, Milan, Italy.
Fiorotto R; Liver Center, Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Mariotti V; School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Kaffe E; Liver Center, Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Seller B; Department of Molecular Medicine (DMM), University of Padova, Padova, Italy.
Sonzogni A; Liver Center, Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Strazzabosco M; Liver Center, Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Cadamuro M; School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.

FASEB J ; 36(6): e22364, 2022 06.

Article en En | MEDLINE | ID: mdl-35593740

Asunto(s)

Quistes; beta Catenina; Animales; Modelos Animales de Enfermedad; Enfermedades Genéticas Congénitas; Péptidos y Proteínas de Señalización Intracelular; Cirrosis Hepática/genética; Cirrosis Hepática/metabolismo; Ratones; ARN Interferente Pequeño; Receptores de Superficie Celular; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; beta Catenina/genética; beta Catenina/metabolismo

Palabras clave

Scribble; YAP; chronic cholangiopathy; congenital hepatic fibrosis; fibrocystin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quistes / Beta Catenina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Italia

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