Association between clinical factors and orofacial dyskinesias in anti-N-methyl-D-aspartate receptor encephalitis.
Brain Behav
; 12(7): e2638, 2022 07.
Article
en En
| MEDLINE
| ID: mdl-35620876
ABSTRACT
BACKGROUND AND PURPOSE:
We aimed to determine whether demographic information, clinical characteristics, laboratory tests, and imaging features are associated with orofacial dyskinesias (OFLD) in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.METHODS:
In this retrospective study, patients who were diagnosed with anti-NMDAR encephalitis were enrolled. All patients' factors, including demographic information, clinical characteristics, laboratory tests, and imaging features, were obtained at the time of hospitalization. The neurological function was assessed using the modified Rankin scale (mRS). Univariate and multivariate logistic regressions were used to examine the associations between clinical factors and OFLD.RESULTS:
In total, 119 patients (median age 28.0 [19.0-41.0] years; 67 females) were recruited. Of 119 patients, 44 (37.0%) had OFLD. OFLD was associated with increased mRS at admission, serum sodium, lumbar puncture pressure, female biologic sex, fever, psychiatric symptoms, seizures, impaired consciousness, autonomic dysfunction, and central hypoventilation in univariate logistic regression, respectively. Multivariate regression analysis revealed that female biologic sex (odds ratios [OR], 4.73; 95% confidence interval [CI], 1.27-17.64; p = .021), increased mRS at admission (OR, 2.09; 95% CI, 1.18-3.71; p = .011), psychiatric symptoms (OR, 7.27; 95% CI, 1.20-43.91; p = .031), and seizures (OR, 5.11; 95% CI, 1.22-21.43; p = .026) were associated with OFLD, after adjusting for confounding factors.CONCLUSIONS:
Our analysis suggests that the following clinical factors are associated with OFLD female biologic sex, increased mRS at admission, psychiatric symptoms, and seizures.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Discinesias
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Encefalitis Antirreceptor N-Metil-D-Aspartato
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Brain Behav
Año:
2022
Tipo del documento:
Article
País de afiliación:
China