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Cross-Talk between Wnt Signaling and Src Tyrosine Kinase.
Min, Jung Ki; Park, Hwee-Seon; Lee, Yoon-Beom; Kim, Jae-Gyu; Kim, Jong-Il; Park, Jae-Bong.
Afiliación
  • Min JK; Department of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, Korea.
  • Park HS; Institute of Cell Differentiation and Aging, Hallym University College of Medicine, Chuncheon 24252, Korea.
  • Lee YB; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
  • Kim JG; Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 03080, Korea.
  • Kim JI; Department of Biochemistry, Hallym University College of Medicine, Chuncheon 25242, Korea.
  • Park JB; Institute of Cell Differentiation and Aging, Hallym University College of Medicine, Chuncheon 24252, Korea.
Biomedicines ; 10(5)2022 May 11.
Article en En | MEDLINE | ID: mdl-35625853
Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has been shown to critical for cancer progression for a variety of tissues. Src activity is regulated by a number of post-translational modifications in response to various stimuli. Phosphorylations of Src Tyr419 (human; 416 in chicken) and Src Tyr530 (human; 527 in chicken) have been known to be critical for activation and inactivation of Src, respectively. Wnt signaling regulates a variety of cellular functions including for development and cell proliferation, and has a role in certain diseases such as cancer. Wnt signaling is carried out through two pathways: ß-catenin-dependent canonical and ß-catenin-independent non-canonical pathways as Wnt ligands bind to their receptors, Frizzled, LRP5/6, and ROR1/2. In addition, many signaling components including Axin, APC, Damm, Dishevelled, JNK kinase and Rho GTPases contribute to these canonical and non-canonical Wnt pathways. However, the communication between Wnt signaling and Src tyrosine kinase has not been well reviewed as Src regulates Wnt signaling through LRP6 tyrosine phosphorylation. GSK-3ß phosphorylated by Wnt also regulates Src activity. As Wnt signaling and Src mutually regulate each other, it is noted that aberrant regulation of these components give rise to various diseases including typically cancer, and as such, merit a closer look.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article