New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696.
J Fungi (Basel)
; 8(5)2022 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-35628710
ABSTRACT
Six new polyketides acrucipentyns A-F (1-6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Acrucipentyns A-E were identified to be the very first examples of chlorine-containing asperpentyn-like compounds. The cytotoxic and antimicrobial activities of the isolated compounds were examined. Acrucipentyns A-F were found as antimicrobial agents, which inhibited sortase A enzyme activity, bacterial growth and biofilm formation of Staphylococcus aureus and decreased LDH release from human keratinocytes HaCaT in S. aureus skin infection in an in vitro model.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Fungi (Basel)
Año:
2022
Tipo del documento:
Article
País de afiliación:
Rusia