Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs.

Hao, Qingqing; Wang, Shuai; Huang, Wenjuan; Zhang, Yinxiang; Pannecouque, Christophe; De Clercq, Erik; Chen, Fener

Hao, Qingqing; Wang, Shuai; Huang, Wenjuan; Zhang, Yinxiang; Pannecouque, Christophe; De Clercq, Erik; Chen, Fener.

Afiliación

Hao Q; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Wang S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
Huang W; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
Zhang Y; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Chen F; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Cent

Bioorg Chem ; 126: 105880, 2022 09.

Article en En | MEDLINE | ID: mdl-35649315

Asunto(s)

Fármacos Anti-VIH; VIH-1; Fármacos Anti-VIH/química; Fármacos Anti-VIH/farmacología; Transcriptasa Inversa del VIH; Modelos Moleculares; Inhibidores de la Transcriptasa Inversa/química; Inhibidores de la Transcriptasa Inversa/farmacología; Relación Estructura-Actividad; Timina/farmacología

Palabras clave

HEPTs; HIV; NNRTIs; Structure-Based Design

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: VIH-1 / Fármacos Anti-VIH Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article País de afiliación: China

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