Metoclopramide effect on esophageal peristalsis in normal human volunteers.
Am J Gastroenterol
; 82(4): 307-10, 1987 Apr.
Article
en En
| MEDLINE
| ID: mdl-3565333
ABSTRACT
There is relatively poor documentation of the effect of metoclopramide on the human esophageal body. We, therefore, studied several parameters of esophageal function in 19 normal volunteers both before and after 20 mg intravenous metoclopramide. Contraction amplitude, wave duration, velocity, and propagation time were increased after metoclopramide. These changes were more pronounced in the distal esophagus. At the most distal manometric recording level located 2 cm above the lower esophageal sphincter, contraction amplitude increased 39% (p less than 0.01) and duration increased 22.5% (p less than 0.01) after metoclopramide. We conclude that in normal subjects metoclopramide has an effect predominant in the distal body of the esophagus.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esófago
/
Metoclopramida
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Gastroenterol
Año:
1987
Tipo del documento:
Article