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Statistical learning in patients in the minimally conscious state.
Xu, Chuan; Li, Hangcheng; Gao, Jiaxin; Li, Lingling; He, Fangping; Yu, Jie; Ling, Yi; Gao, Jian; Li, Jingqi; Melloni, Lucia; Luo, Benyan; Ding, Nai.
Afiliación
  • Xu C; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Li H; Department of Rehabilitation, Hangzhou Mingzhou Brain Rehabilitation Hospital, Hangzhou 311215, China.
  • Gao J; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Sciences, Zhejiang University, Hangzhou 310027, China.
  • Li L; Research Center for Advanced Artificial Intelligence Theory, Zhejiang Lab, Hangzhou 311121, China.
  • He F; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Yu J; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Ling Y; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Gao J; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Li J; Department of Rehabilitation, Hangzhou Mingzhou Brain Rehabilitation Hospital, Hangzhou 311215, China.
  • Melloni L; Department of Rehabilitation, Hangzhou Mingzhou Brain Rehabilitation Hospital, Hangzhou 311215, China.
  • Luo B; New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA.
  • Ding N; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Cereb Cortex ; 33(6): 2507-2516, 2023 03 10.
Article en En | MEDLINE | ID: mdl-35670595
When listening to speech, cortical activity can track mentally constructed linguistic units such as words, phrases, and sentences. Recent studies have also shown that the neural responses to mentally constructed linguistic units can predict the outcome of patients with disorders of consciousness (DoC). In healthy individuals, cortical tracking of linguistic units can be driven by both long-term linguistic knowledge and online learning of the transitional probability between syllables. Here, we investigated whether statistical learning could occur in patients in the minimally conscious state (MCS) and patients emerged from the MCS (EMCS) using electroencephalography (EEG). In Experiment 1, we presented to participants an isochronous sequence of syllables, which were composed of either 4 real disyllabic words or 4 reversed disyllabic words. An inter-trial phase coherence analysis revealed that the patient groups showed similar word tracking responses to real and reversed words. In Experiment 2, we presented trisyllabic artificial words that were defined by the transitional probability between words, and a significant word-rate EEG response was observed for MCS patients. These results suggested that statistical learning can occur with a minimal conscious level. The residual statistical learning ability in MCS patients could potentially be harnessed to induce neural plasticity.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estado Vegetativo Persistente / Aprendizaje Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estado Vegetativo Persistente / Aprendizaje Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: China