Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.
J Infect Dis
; 227(2): 256-260, 2023 01 11.
Article
en En
| MEDLINE
| ID: mdl-35679351
ABSTRACT
BACKGROUND:
Human papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed.METHODS:
We assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV.RESULTS:
Detection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence.CONCLUSIONS:
Detection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Orofaríngeas
/
Infecciones por Virus de Epstein-Barr
/
Infecciones por Papillomavirus
/
Enfermedades de la Boca
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Infect Dis
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos