Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.

Gerlach, Piotr; Garland, William; Lingaraju, Mahesh; Salerno-Kochan, Anna; Bonneau, Fabien; Basquin, Jérôme; Jensen, Torben Heick; Conti, Elena

Gerlach, Piotr; Garland, William; Lingaraju, Mahesh; Salerno-Kochan, Anna; Bonneau, Fabien; Basquin, Jérôme; Jensen, Torben Heick; Conti, Elena.

Afiliación

Gerlach P; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany. Electronic address: p.gerlach@imol.edu.pl.
Garland W; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Lingaraju M; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany.
Salerno-Kochan A; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany.
Bonneau F; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany.
Basquin J; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany.
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Conti E; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, Munich, Germany. Electronic address: conti@biochem.mpg.de.

Mol Cell ; 82(13): 2505-2518.e7, 2022 07 07.

Article en En | MEDLINE | ID: mdl-35688157

Asunto(s)

Exosomas; ARN; Núcleo Celular/genética; Núcleo Celular/metabolismo; ARN Helicasas DEAD-box/metabolismo; ADN Helicasas/metabolismo; Complejo Multienzimático de Ribonucleasas del Exosoma/metabolismo; Exosomas/genética; Exosomas/metabolismo; Humanos; Unión Proteica; ARN/genética; ARN/metabolismo; ARN Helicasas/metabolismo; Estabilidad del ARN/genética

Palabras clave

NEXT; RNA degradation; RNA exosome; RNA processing; conformational regulation; cryo-EM; domain swapping; helicase; non-coding RNAs; pervasive transcription

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN / Exosomas Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article

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