Heterogeneity in statin responses explained by variation in the human gut microbiome.

Wilmanski, Tomasz; Kornilov, Sergey A; Diener, Christian; Conomos, Matthew P; Lovejoy, Jennifer C; Sebastiani, Paola; Orwoll, Eric S; Hood, Leroy; Price, Nathan D; Rappaport, Noa; Magis, Andrew T; Gibbons, Sean M

Wilmanski, Tomasz; Kornilov, Sergey A; Diener, Christian; Conomos, Matthew P; Lovejoy, Jennifer C; Sebastiani, Paola; Orwoll, Eric S; Hood, Leroy; Price, Nathan D; Rappaport, Noa; Magis, Andrew T; Gibbons, Sean M.

Afiliación

Wilmanski T; Institute for Systems Biology, Seattle, WA 98109, USA.
Kornilov SA; Institute for Systems Biology, Seattle, WA 98109, USA.
Diener C; Institute for Systems Biology, Seattle, WA 98109, USA.
Conomos MP; University of Washington, Genetic Analysis Center, Seattle, WA 98195, USA.
Lovejoy JC; Institute for Systems Biology, Seattle, WA 98109, USA.
Sebastiani P; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA.
Orwoll ES; Oregon Health Sciences University, Portland, OR 97239, USA.
Hood L; Institute for Systems Biology, Seattle, WA 98109, USA.
Price ND; Institute for Systems Biology, Seattle, WA 98109, USA; Thorne HealthTech, New York, NY 10019, USA.
Rappaport N; Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address: noa.rappaport@isbscience.org.
Magis AT; Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address: amagis@isbscience.org.
Gibbons SM; Institute for Systems Biology, Seattle, WA 98109, USA; University of Washington, Department of Bioengineering, Seattle, WA 98105, USA; University of Washington, eScience Institute, Seattle, WA 98195, USA. Electronic address: sgibbons@isbscience.org.

Med ; 3(6): 388-405.e6, 2022 06 10.

Article en En | MEDLINE | ID: mdl-35690059

Asunto(s)

Diabetes Mellitus Tipo 2; Microbioma Gastrointestinal; Inhibidores de Hidroximetilglutaril-CoA Reductasas; Microbiota; Estudios Transversales; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Microbioma Gastrointestinal/genética; Humanos; Inhibidores de Hidroximetilglutaril-CoA Reductasas/efectos adversos; ARN Ribosómico 16S/genética

Palabras clave

Translation to patients; cardiometabolic health; microbiome; personalized medicine; pharmacogenomics; pharmacomicrobiomics; statins

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Hidroximetilglutaril-CoA Reductasas / Diabetes Mellitus Tipo 2 / Microbiota / Microbioma Gastrointestinal Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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