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A COMMON FINDING IN FOVEAL-SPARING EXTENSIVE MACULAR ATROPHY WITH PSEUDODRUSEN IMPLICATES BASAL LAMINAR DEPOSITS.
Fragiotta, Serena; Parravano, Mariacristina; Sacconi, Riccardo; Costanzo, Eliana; Viggiano, Pasquale; Prascina, Francesco; Capuano, Vittorio; Souied, Eric H; Querques, Giuseppe.
Afiliación
  • Fragiotta S; UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy.
  • Parravano M; IRCCS-Fondazione Bietti, Rome, Italy.
  • Sacconi R; Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy ; and.
  • Costanzo E; IRCCS-Fondazione Bietti, Rome, Italy.
  • Viggiano P; IRCCS-Fondazione Bietti, Rome, Italy.
  • Prascina F; Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy ; and.
  • Capuano V; Ophthalmology, Centre Hospitalier Intercommunal De Creteil, Creteil, France .
  • Souied EH; Ophthalmology, Centre Hospitalier Intercommunal De Creteil, Creteil, France .
  • Querques G; Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy ; and.
Retina ; 42(7): 1319-1329, 2022 07 01.
Article en En | MEDLINE | ID: mdl-35696630
PURPOSE: To characterize structural and clinical alterations preceding the diffuse macular atrophy in extensive macular atrophy with pseudodrusen (EMAP) and their evolution toward atrophic changes. METHODS: A retrospective chart review was performed of patients with early-onset reticular pseudodrusen (i.e., pre-EMAP) younger than 55 years and EMAP with foveal sparing. Patients were included if they had complete medical records and multimodal imaging. RESULTS: A total of 12 patients were reviewed, of whom 4 of 12 patients (7 eyes) presented a pre-EMAP stage, characterized by the presence of pseudodrusen-like deposits without atrophic changes, while the remaining 8 of 12 patients (10 eyes) exhibited EMAP with foveal sparing (60.1 ± 6.4 years). Subretinal deposits of various stages tended to fade, leaving subretinal pigment epithelium accumulation of hyperreflective material with a physical separation between the retinal pigment epithelium-basal lamina and the Bruch membrane, along with the persistence of hyperreflective material after retinal pigment epithelium loss. These findings preceded atrophy development in a pre-EMAP stage and the EMAP stage with foveal sparing. CONCLUSION: Our findings presented distinct multimodal imaging features in eyes with reticular pseudodrusen depicting a peculiar phenotype of rapidly progressing atrophy in midlife. The disease spectrum may include other forms of geographic atrophy allied by thickened basal laminar deposits.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Drusas Retinianas / Degeneración Macular Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Retina Año: 2022 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Drusas Retinianas / Degeneración Macular Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Retina Año: 2022 Tipo del documento: Article País de afiliación: Italia