A switchable Cas12a enabling CRISPR-based direct histone deacetylase activity detection.

Kang, Wenyuan; Liu, Lin; Yu, Peihang; Zhang, Tianyi; Lei, Chunyang; Nie, Zhou

Kang, Wenyuan; Liu, Lin; Yu, Peihang; Zhang, Tianyi; Lei, Chunyang; Nie, Zhou.

Afiliación

Kang W; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China.
Liu L; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China.
Yu P; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China.
Zhang T; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China.
Lei C; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China. Electronic address: cylei@hnu.edu.cn.
Nie Z; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, PR China. Electronic address: niezhou.hnu@gmail.com.

Biosens Bioelectron ; 213: 114468, 2022 Oct 01.

Article en En | MEDLINE | ID: mdl-35700604

Asunto(s)

Técnicas Biosensibles; Sistemas CRISPR-Cas; Acetilación; Sistemas CRISPR-Cas/genética; Histona Desacetilasas/genética; Técnicas de Amplificación de Ácido Nucleico

Palabras clave

Biosensing; CRISPR-Cas; Deep learning; Histone deacetylase; Signal amplification

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Sistemas CRISPR-Cas Tipo de estudio: Diagnostic_studies Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article

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