[The role and molecular mechanism of miR-494 in disease development and progression].
Sheng Li Xue Bao
; 74(3): 495-504, 2022 Jun 25.
Article
en Zh
| MEDLINE
| ID: mdl-35770647
ABSTRACT
MicroRNA-494 (miR-494) is a small non-coding RNA located in chromosome 14q32.31 and regulates post-transcriptional gene expression by promoting the degradation of its target mRNAs via binding to the 3' untranslated regions (3'UTR). It has been reported that miR-494 plays an important role in the occurrence, development and prognosis of various diseases. Several signaling pathways modulated by miR-494 including the PTEN/PI3K/AKT, nuclear factor κ-B (NF-κB), mitogen-activated protein kinase (MAPK), transforming growth factor-ß (TGF-ß)/SMAD, and Wnt/ß-catenin are associated with physiological regulation and pathological process in many diseases. The stably expression of miR-494 in the blood stream suggests its potential as a biological marker for disease diagnosis, treatment, and prognosis. Based on recent research, we summarize the role and molecular mechanism of miR-494 in disease development and progression. We also discuss its potential as a marker for clinical diagnosis and prognosis of various diseases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilinositol 3-Quinasas
/
MicroARNs
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2022
Tipo del documento:
Article
País de afiliación:
China