Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection.

Maponga, Tongai G; Jeffries, Montenique; Tegally, Houriiyah; Sutherland, Andrew; Wilkinson, Eduan; Lessells, Richard J; Msomi, Nokukhanya; van Zyl, Gert; de Oliveira, Tulio; Preiser, Wolfgang

Maponga, Tongai G; Jeffries, Montenique; Tegally, Houriiyah; Sutherland, Andrew; Wilkinson, Eduan; Lessells, Richard J; Msomi, Nokukhanya; van Zyl, Gert; de Oliveira, Tulio; Preiser, Wolfgang.

Afiliación

Maponga TG; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
Jeffries M; Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Sutherland A; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
Wilkinson E; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Lessells RJ; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Msomi N; Discipline of Virology, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service (NHLS), University of KwaZulu-Natal, Durban, South Africa.
van Zyl G; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
de Oliveira T; National Health Laboratory Service, Tygerberg Business Unit, Cape Town, South Africa.
Preiser W; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Clin Infect Dis ; 76(3): e522-e525, 2023 02 08.

Article en En | MEDLINE | ID: mdl-35793242

ABSTRACT

ABSTRACT

A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.

Asunto(s)

COVID-19; Infecciones por VIH; Femenino; Humanos; Adulto Joven; Adulto; SARS-CoV-2/genética; Mutación; Infecciones por VIH/complicaciones; Infecciones por VIH/tratamiento farmacológico

Palabras clave

SARS-CoV-2; antiretroviral therapy; immunocompromised; persistent infection; uncontrolled HIV infection

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / COVID-19 Límite: Adult / Female / Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Sudáfrica

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