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Bola-Amphiphilic Glycodendrimers: New Carbohydrate-Mimicking Scaffolds to Target Carbohydrate-Binding Proteins.
Zhang, Wenzheng; Dhumal, Dinesh; Zhu, Xiaolei; Ralahy, Brigino; Ellert-Miklaszewska, Aleksandra; Wu, Jing; Laurini, Erik; Yao, Yi-Wen; Kao, Chai-Lin; Iovanna, Juan L; Pricl, Sabrina; Kaminska, Bozena; Xia, Yi; Peng, Ling.
Afiliación
  • Zhang W; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research Innovative Drug Research Center School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China.
  • Dhumal D; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Zhu X; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Ralahy B; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Ellert-Miklaszewska A; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Wu J; Laboratory of Molecular Neurobiology, Neurobiology Center, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Warsaw, 02-093, Poland.
  • Laurini E; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Yao YW; Molecular Biology and Nanotechnology (MolBNL@UniTS) Laboratory DEA, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy.
  • Kao CL; Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325, Equipe Labellisé par La Ligue, Aix-Marseille Université, CNRS, Marseille, 13288, France.
  • Iovanna JL; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
  • Pricl S; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
  • Kaminska B; Centre de Recherche en Cancérologie de Marseille (CRCM) INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, 13288, France.
  • Xia Y; Molecular Biology and Nanotechnology (MolBNL@UniTS) Laboratory DEA, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy.
  • Peng L; Department of General Biophysics Faculty of Biology and Environmental Protection, University of Lodz, Lódz, 90-236, Poland.
Chemistry ; 28(58): e202201400, 2022 Oct 18.
Article en En | MEDLINE | ID: mdl-35820051
ABSTRACT
Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dendrímeros / Manosa Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dendrímeros / Manosa Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article