Local Patterns in 2-Year T1ρ and T2 Changes of Hip Cartilage Are Related to Sex and Functional Data: A Prospective Evaluation on Hip Osteoarthritis Participants.

ABSTRACT

BACKGROUND: Although T1ρ and T2 have emerged as early indicators for hip osteoarthritis (OA), there is little information regarding longitudinal changes across the cartilage in the early stages of this disease. PURPOSE: To characterize the variability in 2-year hip cartilage T1ρ and T2 changes and investigate associations between these patterns of change and common indicators of hip OA. STUDY TYPE Prospective. POPULATION A total of 25 women (age 51.9 ± 16.3 years old; BMI 22.6 ± 2.0 kg/m2 ) and 17 men (age 55.8 ± 14.9 years old; body mass index (BMI) 24.4 ± 3.8 kg/m2 ) who were healthy or with early-to-moderate hip OA. FIELD STRENGTH/SEQUENCE A 3 T MRI (GE), 3D combined T1ρ /T2 magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots. ASSESSMENT Principal component (PC) analysis of Z-score difference maps of 2-year changes in hip cartilage T1ρ and T2 relaxation times, participant hip disability and osteoarthritis outcome scores (HOOS) and functional tests at 2-year follow-up. STATISTICAL TESTS Shapiro-Wilk test, unpaired t-tests, Kruskal Wallis tests, Pearson or Spearman (ρ) correlations. Significance was set at P < 0.05. RESULTS: Women (-6.40 ± 14.48) had significantly lower T1ρ PC1 scores than men (10.05 ± 26.15). T1ρ PC4 was significantly correlated with HOOSsport , HOOSsymptoms , HOOSpain , HOOSadl , and HOOSqol at 2-year follow-up (ρ [0.36, 0.50]). T1ρ PC2 and PC4 were significantly correlated with 30-second chair test (ρ = -0.39 and ρ = 0.24, respectively) and side plank (ρ = -0.32 and ρ = 0.21). T1ρ and T2 PC2 were significantly correlated with 40 m walk test (ρ = 0.34 and ρ = 0.31) and 30-second chair rise test (ρ = -0.39 and ρ = -0.32). DATA CONCLUSION: Men exhibited accelerated T1ρ increases across the femoral cartilage compared to women, suggesting sex should be considered when evaluating early hip OA. Participants with poorer HOOS and function exhibited greater T1ρ and T2 increases in superior and anterior femoral cartilage and greater T1ρ increases in the anterior femoral cartilage. These patterns of short-term relaxometry increases could indicate hip OA progression. EVIDENCE LEVEL 2 TECHNICAL EFFICACY Stage 3.