Double-negative T cells mediate M1 polarization of microglial cells via TNF-&#945;-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice.

Han, Chenyang; Sheng, Yongjia; Wang, Jin; Zhou, Xiaohong; Li, Wenyan; Zhang, Caiqun; Guo, Li; Yang, Yi

Double-negative T cells mediate M1 polarization of microglial cells via TNF-α-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice.

Han, Chenyang; Sheng, Yongjia; Wang, Jin; Zhou, Xiaohong; Li, Wenyan; Zhang, Caiqun; Guo, Li; Yang, Yi.

Afiliación

Han C; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Sheng Y; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Wang J; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Zhou X; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Li W; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Zhang C; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Guo L; Department of Center Laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Yang Y; Department of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.

J Cell Physiol ; 237(10): 3860-3871, 2022 10.

Article en En | MEDLINE | ID: mdl-35866513

Asunto(s)

Enfermedad de Alzheimer; Disfunción Cognitiva; Enfermedad de Alzheimer/patología; Animales; Disfunción Cognitiva/metabolismo; Inflamasomas/metabolismo; Ratones; Microglía/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Enfermedades Neuroinflamatorias; ARN Interferente Pequeño/metabolismo; Receptores Tipo I de Factores de Necrosis Tumoral/metabolismo; Linfocitos T/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Alzheimer's disease; M1 polarization; cognitive impairment; double-negative T cells; microglial cells

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google