Analysis of STMN2 CA repeats in italian ALS patients shows no association.
Amyotroph Lateral Scler Frontotemporal Degener
; 24(1-2): 152-154, 2023 Feb.
Article
en En
| MEDLINE
| ID: mdl-35876065
ABSTRACT
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease caused by a complex interaction of genetic and environmental factors. Recently, a polymorphic intronic CA repeat in STMN2 gene has been proposed as risk factor for ALS. The presence of long/long CA genotype, especially if one allele had 24 CA, was reported to be significantly associated with the disease in a cohort of sporadic ALS patients. We tested an Italian cohort of 366 ALS patients and 353 healthy controls and we found no association between CA length and ALS risk.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Esclerosis Amiotrófica Lateral
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Amyotroph Lateral Scler Frontotemporal Degener
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia