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Sexual Mixing by HIV Status and Pre-exposure Prophylaxis Use Among Men Who Have Sex With Men: Addressing Information Bias.
Maloney, Kevin M; Benkeser, David; Sullivan, Patrick S; Kelley, Colleen; Sanchez, Travis; Jenness, Samuel M.
Afiliación
  • Maloney KM; From the Department of Epidemiology, Emory University, Atlanta, GA.
  • Benkeser D; Department of Population Health Sciences, Georgia State University, Atlanta, GA.
  • Sullivan PS; Department of Biostatistics, Emory University, Atlanta, GA.
  • Kelley C; From the Department of Epidemiology, Emory University, Atlanta, GA.
  • Sanchez T; Department of Medicine, Emory University, Atlanta, GA.
  • Jenness SM; From the Department of Epidemiology, Emory University, Atlanta, GA.
Epidemiology ; 33(6): 808-816, 2022 11 01.
Article en En | MEDLINE | ID: mdl-35895578
ABSTRACT

BACKGROUND:

Population-level estimates of sexual network mixing for parameterizing prediction models of pre-exposure prophylaxis (PrEP) effectiveness are needed to inform prevention of HIV transmission among men who have sex with men (MSM). Estimates obtained by egocentric sampling are vulnerable to information bias due to incomplete respondent knowledge.

METHODS:

We estimated patterns of serosorting and PrEP sorting among MSM in the United States using data from a 2017-2019 egocentric sexual network study. Respondents served as proxies to report the HIV status and PrEP use of recent sexual partners. We contrasted results from a complete-case analysis (unknown HIV and PrEP excluded) versus a bias analysis with respondent-reported data stochastically reclassified to simulate unobserved self-reported data from sexual partners.

RESULTS:

We found strong evidence of preferential partnering across analytical approaches. The bias analysis showed concordance between sexual partners of HIV diagnosis and PrEP use statuses for MSM with diagnosed HIV (39%; 95% simulation interval 31, 46), MSM who used PrEP (32%; 21, 37), and MSM who did not use PrEP (83%; 79, 87). The fraction of partners with diagnosed HIV was higher among MSM who used PrEP (11%; 9, 14) compared with MSM who did not use PrEP (4%; 3, 5). Comparatively, across all strata of respondents, the complete-case analysis overestimated the fractions of partners with diagnosed HIV or PrEP use.

CONCLUSIONS:

We found evidence consistent with HIV and PrEP sorting among MSM, which may decrease the population-level effectiveness of PrEP. Bias analyses can improve mixing estimates for parameterization of transmission models.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Profilaxis Pre-Exposición / Minorías Sexuales y de Género Tipo de estudio: Prognostic_studies Límite: Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Epidemiology Asunto de la revista: EPIDEMIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Gabón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Profilaxis Pre-Exposición / Minorías Sexuales y de Género Tipo de estudio: Prognostic_studies Límite: Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Epidemiology Asunto de la revista: EPIDEMIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Gabón