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Changes in the Vaginal Microbiota of Women With Secondary Localized Provoked Vulvodynia.
Awad-Igbaria, Yaseen; Palzur, Eilam; Nasser, Manal; Vieira-Baptista, Pedro; Bornstein, Jacob.
Afiliación
  • Palzur E; The Research Institute of Galilee Medical Center, Nahariya, Israel.
  • Nasser M; Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel.
  • Vieira-Baptista P; Department of Obstetrics and Gynecology, Hospital Lusíadas Lisboa, Porto, Portugal.
J Low Genit Tract Dis ; 26(4): 339-344, 2022 Oct 01.
Article en En | MEDLINE | ID: mdl-35943448
ABSTRACT

OBJECTIVE:

The etiology of localized provoked vulvodynia (LPV) remains unknown, but observations suggest the involvement of the vaginal microbiota. We examined the vaginal microbiota of women with LPV and healthy controls, upon after a low-oxalate diet (LOD). MATERIALS AND

METHODS:

A total of 9 women diagnosed with secondary LPV and 21 healthy controls were recruited from the Galilee Medical Center in Israel and subjected to prospective evaluations of their vaginal microbiota. Total DNA was extracted from vaginal discharge samples provided before and after following LOD for 3 weeks and was then subjected to 16S sequencing. Data obtained were then used to evaluate α and ß diversity, identify differentially abundant bacterial taxa in LPV, and determine their impact on the metabolism.

RESULTS:

These evaluations revealed decreased diversity in the vaginal microbiota of women with LPV and identified the Ochrobactrum genus and Pseudomonadaceae family as indicators for LPV. In addition, we identified 23 differentially expressed bacterial metabolic pathways between the LPV and control samples and revealed that LOD could induce changes in the ß diversity of LPV vaginal microbiomes, which was further supported by some degree of pain reduction in patients.

CONCLUSIONS:

Localized provoked vulvodynia and LOD were associated with shifts in the vaginal microbiota. However, the impact of these changes on the development of LPV requires additional studies with a larger cohort.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vulvodinia / Microbiota Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Low Genit Tract Dis Asunto de la revista: GINECOLOGIA Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vulvodinia / Microbiota Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Low Genit Tract Dis Asunto de la revista: GINECOLOGIA Año: 2022 Tipo del documento: Article