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Hippocampal Functional Connectivity in Parkinson's Disease.
Llewelyn, Landis E; Kornisch, Myriam; Park, Hyejin; Ikuta, Toshikazu.
Afiliación
  • Llewelyn LE; Department of Occupational Therapy, Belmont University, Nashville, Tennessee, USA.
  • Kornisch M; Department of Communication Sciences and Disorders, University of Mississippi, University, Mississippi, USA.
  • Park H; Department of Communication Sciences and Disorders, University of Mississippi, University, Mississippi, USA.
  • Ikuta T; Department of Communication Sciences and Disorders, University of Mississippi, University, Mississippi, USA.
Neurodegener Dis ; 22(1): 29-33, 2022.
Article en En | MEDLINE | ID: mdl-35944512
BACKGROUND: While the hippocampus is not part of the nigrostriatal dopaminergic pathway, influence of Parkinson's disease (PD) on the hippocampus has been consistently implicated. However, it is not clear how the hippocampal changes contribute to the pathology of PD. OBJECTIVES: We aimed to elucidate the physiological changes of the hippocampus in its orchestration with the rest of the brain. METHODS: Using the resting-state fMRI data from Parkinson's Progression Markers Initiative (PPMI), functional connectivity of the hippocampus was analyzed in 93 individuals with PD and 18 individuals without PD. RESULTS: A whole brain voxel-wise analysis showed that the bilateral paracingulate gyri were less connected to the hippocampus in the PD group compared to the control group. The hippocampus-paracingulate dysconnectivity did not show association with cognitive indices. CONCLUSIONS: The hippocampus in PD shows dysconnectivity to the paracingulate gyri.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Revista: Neurodegener Dis Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Revista: Neurodegener Dis Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos