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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Simpson, Joshua B; Sekela, Josh J; Graboski, Amanda L; Borlandelli, Valentina B; Bivins, Marissa M; Barker, Natalie K; Sorgen, Alicia A; Mordant, Angie L; Johnson, Rebecca L; Bhatt, Aadra P; Fodor, Anthony A; Herring, Laura E; Overkleeft, Hermen; Lee, John R; Redinbo, Matthew R.
Afiliación
  • Simpson JB; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Sekela JJ; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Graboski AL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Borlandelli VB; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • Bivins MM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Barker NK; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Sorgen AA; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA.
  • Mordant AL; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Johnson RL; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Bhatt AP; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Fodor AA; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
  • Herring LE; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Overkleeft H; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • Lee JR; Department of Medicine, Division of Nephrology and Hypertension, New York, New York, USA.
  • Redinbo MR; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gut Microbes ; 14(1): 2107289, 2022.
Article en En | MEDLINE | ID: mdl-35953888
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: Gut Microbes Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: Gut Microbes Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos