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Macrocycle molecule-based cryoprotectants for ice recrystallization inhibition and cell cryopreservation.
Hu, Bing; Li, Guo-Kai; Ai, Guo-Min; Zhang, Man; Su, Shan-Shan; He, Xu; Li, Xiao-Liu; Wang, Ke-Rang.
Afiliación
  • Hu B; College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. lixl@hbu.edu.cn.
  • Li GK; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
  • Ai GM; College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. lixl@hbu.edu.cn.
  • Zhang M; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
  • Su SS; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • He X; College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. lixl@hbu.edu.cn.
  • Li XL; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
  • Wang KR; College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. lixl@hbu.edu.cn.
J Mater Chem B ; 10(36): 6922-6927, 2022 09 21.
Article en En | MEDLINE | ID: mdl-35979758
ABSTRACT
Cyclodextrin-based cryoprotectants were developed. α-TMCD, which can be easily put into large-scale production, showed enhanced cell viabilities of 19.97 ± 0.78%, 13.93 ± 4.46% and 19.10 ± 0.95% against GES-1, hucMSCs and A549 cells. Moreover, the viable cells observed by light microscope imaging showed that the enhanced hucMSC cell number percentage of α-TMCD was 103.2%. An α-TMCD-DMSO-based CPA exhibited an enhanced cryoprotective effect by a mechanism of DMSO-enhanced cell penetrating effect and α-TMCD-DMSO synergistically enhanced IMA ability. α-TMCD exhibited potential for the discovery of macrocycle-molecule-based cryoprotectants.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Crioprotectores / Ciclodextrinas Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Crioprotectores / Ciclodextrinas Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article