H172Y mutation perturbs the S1 pocket and nirmatrelvir binding of SARS-CoV-2 main protease through a nonnative hydrogen bond.

de Oliveira, Vinicius Martins; Ibrahim, Mohamed Fourad; Sun, Xinyuanyuan; Hilgenfeld, Rolf; Shen, Jana

de Oliveira, Vinicius Martins; Ibrahim, Mohamed Fourad; Sun, Xinyuanyuan; Hilgenfeld, Rolf; Shen, Jana.

Afiliación

de Oliveira VM; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Ibrahim MF; Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Sun X; Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Hilgenfeld R; Institute of Molecular Medicine, University of Lübeck, Lübeck, Germany.
Shen J; German Center for Infection Research (DZIF), Hamburg - Lübeck - Borstel - Riems Site, University of Lübeck, Lübeck, Germany.

Res Sq ; 2022 Aug 09.

Article en En | MEDLINE | ID: mdl-35982654

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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