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Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
Koester, Dennis C; Marx, Vanessa M; Williams, Sarah; Jiricek, Jan; Dauphinais, Maxime; René, Olivier; Miller, Sarah L; Zhang, Lei; Patra, Debjani; Chen, Yen-Liang; Cheung, Harry; Gable, Jonathan; Lakshminarayana, Suresh B; Osborne, Colin; Galarneau, Jean-Rene; Kulkarni, Upendra; Richmond, Wendy; Bretz, Angela; Xiao, Linda; Supek, Frantisek; Wiesmann, Christian; Honnappa, Srinivas; Be, Celine; Mäser, Pascal; Kaiser, Marcel; Ritchie, Ryan; Barrett, Michael P; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S.
Afiliación
  • Koester DC; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Marx VM; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Williams S; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Jiricek J; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Dauphinais M; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • René O; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Miller SL; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Zhang L; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
  • Patra D; Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Chen YL; Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Cheung H; Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Gable J; Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Lakshminarayana SB; Pharmacokinetic Sciences, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Osborne C; Pharmacokinetic Sciences, Pharmacology and Comparative Medicine, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Galarneau JR; Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Kulkarni U; Chemical and Pharmaceutical Profiling, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Richmond W; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.
  • Bretz A; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.
  • Xiao L; Pharmacology, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
  • Supek F; Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.
  • Wiesmann C; Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.
  • Honnappa S; Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.
  • Be C; Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.
  • Mäser P; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.
  • Kaiser M; University of Basel, CH 4000 Basel, Switzerland.
  • Ritchie R; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.
  • Barrett MP; University of Basel, CH 4000 Basel, Switzerland.
  • Diagana TT; University of Glasgow, University Place, Glasgow G12 8TA, U.K.
  • Sarko C; University of Glasgow, University Place, Glasgow G12 8TA, U.K.
  • Rao SPS; Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.
J Med Chem ; 65(17): 11776-11787, 2022 09 08.
Article en En | MEDLINE | ID: mdl-35993839
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinolinas / Trypanosoma / Tripanosomiasis Africana Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinolinas / Trypanosoma / Tripanosomiasis Africana Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos