Direct effects of biguanides on glucose utilization in vitro.
Metabolism
; 36(8): 774-6, 1987 Aug.
Article
en En
| MEDLINE
| ID: mdl-3600289
ABSTRACT
The effect of the biguanides metformin and phenformin on glucose utilization in isolated cells was studied with IM-9 human lymphocytes. Both agents stimulated glucose consumption from the incubation media. Detectable effects of metformin were seen at 33 mumol/L and detectable effects of phenformin were seen at 1.7 mumol/L. Both agents, at similar concentrations, also stimulated [3H] 2-deoxy-D-glucose uptake. Studies with phenformin indicated that biguanides increase the Vmax of uptake without changing the Km. In contrast to the biguanides, IM-9 cells insulin did not influence either glucose consumption or [3H] 2-deoxy-D-glucose uptake. These data provide evidence, therefore, that biguanides may directly influence the cellular utilization of glucose.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenformina
/
Glucemia
/
Linfocitos
/
Metformina
Límite:
Humans
Idioma:
En
Revista:
Metabolism
Año:
1987
Tipo del documento:
Article