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An open-label, phase I/II trial to determine the maximum tolerated dose and investigate safety, pharmacokinetics and efficacy of BI 836858, an unconjugated anti-CD33 monoclonal antibody, in combination with decitabine in patients with acute myeloid leukemia.
Fiedler, Walter; Montesinos, Pau; Schliemann, Christoph; Middeke, Jan; Vasu, Sumithira; Scholz, Christian W; Esteve, Jordi; Mondal, Shoubhik; Rüter, Björn; Burkard, Ute; Osswald, Annika; Blum, William.
Afiliación
  • Fiedler W; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg.
  • Montesinos P; Hospital Universitari i Politecnic La Fe, Valencia, Spain; CIBERONC, Instituto Carlos III, Madrid.
  • Schliemann C; Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster.
  • Middeke J; Uniklinikum Dresden, Dresden.
  • Vasu S; Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH.
  • Scholz CW; Department of Hematology and Oncology, Vivantes Klinikum Am Urban, Berlin.
  • Esteve J; Hematology Department, Hospital Clínic of Barcelona, IDIBAPS, University of Barcelona, Barcelona.
  • Mondal S; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT.
  • Rüter B; BoehringeaBoehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Rissr Ingelheim Pharma GmbH and Co. KG, Biberach/Riss.
  • Burkard U; Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss.
  • Osswald A; Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss.
  • Blum W; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA. william.g.blum@emory.edu.
Haematologica ; 107(12): 2977-2982, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36005556
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica Límite: Humans Idioma: En Revista: Haematologica Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica Límite: Humans Idioma: En Revista: Haematologica Año: 2022 Tipo del documento: Article