Quantal analysis of paired-pulse facilitation in guinea pig hippocampal slices.
Neurosci Lett
; 77(2): 187-92, 1987 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-3601229
ABSTRACT
Intracellular excitatory postsynaptic potentials (EPSPs) were recorded in area CA1 of hippocampal slices from guinea pigs. With paired-pulse stimulation of stratum radiatum, the second stimulus (interval of 40-50 ms) produced an EPSP with enlarged amplitude. Two methods of quantal analysis showed an increase in quantal content of the facilitated EPSP and a smaller increase in quantal size. The correlation between amplitudes of the first and second EPSP was usually insignificant. The results favour a presynaptic location of the mechanisms of the paired-pulse facilitation and suggest increases in the average of transmitter quanta released by presynaptic volley as well as increases in the amount of transmitter in each quantum.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1987
Tipo del documento:
Article