Most cancers carry a substantial deleterious load due to Hill-Robertson interference.

Tilk, Susanne; Tkachenko, Svyatoslav; Curtis, Christina; Petrov, Dmitri A; McFarland, Christopher D

Tilk, Susanne; Tkachenko, Svyatoslav; Curtis, Christina; Petrov, Dmitri A; McFarland, Christopher D.

Afiliación

Tilk S; Department of Biology, Stanford University, Stanford, United States.
Tkachenko S; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Curtis C; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, United States.
Petrov DA; Department of Genetics, Stanford University School of Medicine, Stanford, United States.
McFarland CD; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, United States.

Elife ; 112022 09 01.

Article en En | MEDLINE | ID: mdl-36047771

Asunto(s)

Neoplasias; Selección Genética; Evolución Molecular; Variación Genética; Humanos; Modelos Genéticos; Mutación; Neoplasias/genética; Recombinación Genética

Palabras clave

Hill-Robertson interference; cancer evolution; evolutionary biology; genetics; genomics; human; mutation load

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Selección Genética / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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