Several non-salt and solid thienopyridine derivatives as oral P2Y<sub>12</sub> receptor inhibitors with good stability.

Liu, Lei; Li, Lingjun; Yuan, Jing; Liu, Wei; Li, Yuquan; Zhang, Shijun; Huang, Changjiang

Several non-salt and solid thienopyridine derivatives as oral P2Y₁₂ receptor inhibitors with good stability.

Liu, Lei; Li, Lingjun; Yuan, Jing; Liu, Wei; Li, Yuquan; Zhang, Shijun; Huang, Changjiang.

Afiliación

Liu L; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Li L; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Yuan J; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Liu W; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Li Y; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Zhang S; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301
Huang C; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301

Bioorg Med Chem Lett ; 75: 128969, 2022 11 01.

Article en En | MEDLINE | ID: mdl-36058469

Asunto(s)

Inhibidores de Agregación Plaquetaria; Tienopiridinas; Clopidogrel/farmacología; Citocromo P-450 CYP2C19; Inhibidores de Agregación Plaquetaria/farmacología; Clorhidrato de Prasugrel/farmacología; Antagonistas del Receptor Purinérgico P2Y/farmacología; Receptores Purinérgicos P2Y12; Tiofenos/farmacología

Palabras clave

Clopidogrel resistance; Hygroscopicity; P2Y(12) receptor inhibitors; Prodrug design; Stability; Thienopyridine derivatives

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Agregación Plaquetaria / Tienopiridinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article

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