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The cAMP/PKA/CREB and TGFß/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.
Fujishita, Teruaki; Kojima, Yasushi; Kajino-Sakamoto, Rie; Mishiro-Sato, Emi; Shimizu, Yasuhiro; Hosoda, Waki; Yamaguchi, Rui; Taketo, Makoto Mark; Aoki, Masahiro.
Afiliación
  • Fujishita T; Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
  • Kojima Y; Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
  • Kajino-Sakamoto R; Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
  • Mishiro-Sato E; Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
  • Shimizu Y; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
  • Hosoda W; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
  • Yamaguchi R; Division of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
  • Taketo MM; Department of Cancer Informatics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
  • Aoki M; Colon Cancer Project, Kyoto University Hospital-iACT, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan.
Cancer Res ; 82(22): 4179-4190, 2022 11 15.
Article en En | MEDLINE | ID: mdl-36066360
ABSTRACT

SIGNIFICANCE:

This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Res Año: 2022 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Res Año: 2022 Tipo del documento: Article País de afiliación: Japón