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Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus.
Zhao, Fangzhu; Berndsen, Zachary T; Pedreño-Lopez, Nuria; Burns, Alison; Allen, Joel D; Barman, Shawn; Lee, Wen-Hsin; Chakraborty, Srirupa; Gnanakaran, Sandrasegaram; Sewall, Leigh M; Ozorowski, Gabriel; Limbo, Oliver; Song, Ge; Yong, Peter; Callaghan, Sean; Coppola, Jessica; Weisgrau, Kim L; Lifson, Jeffrey D; Nedellec, Rebecca; Voigt, Thomas B; Laurino, Fernanda; Louw, Johan; Rosen, Brandon C; Ricciardi, Michael; Crispin, Max; Desrosiers, Ronald C; Rakasz, Eva G; Watkins, David I; Andrabi, Raiees; Ward, Andrew B; Burton, Dennis R; Sok, Devin.
Afiliación
  • Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Berndsen ZT; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Pedreño-Lopez N; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Burns A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Allen JD; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Barman S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Lee WH; Department of Pathology, George Washington University, Washington, DC, 20037, USA.
  • Chakraborty S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Gnanakaran S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Sewall LM; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ozorowski G; School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
  • Limbo O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Song G; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Yong P; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Callaghan S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Coppola J; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Weisgrau KL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Lifson JD; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
  • Nedellec R; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
  • Voigt TB; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Laurino F; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Louw J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Rosen BC; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ricciardi M; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Crispin M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Desrosiers RC; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Rakasz EG; IAVI, New York, NY, 10004, USA.
  • Watkins DI; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Andrabi R; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Sok D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Nat Commun ; 13(1): 5236, 2022 09 06.
Article en En | MEDLINE | ID: mdl-36068229
ABSTRACT
SIVmac239 infection of macaques is a favored model of human HIV infection. However, the SIVmac239 envelope (Env) trimer structure, glycan occupancy, and the targets and ability of neutralizing antibodies (nAbs) to protect against SIVmac239 remain unknown. Here, we report the isolation of SIVmac239 nAbs that recognize a glycan hole and the V1/V4 loop. A high-resolution structure of a SIVmac239 Env trimer-nAb complex shows many similarities to HIV and SIVcpz Envs, but with distinct V4 features and an extended V1 loop. Moreover, SIVmac239 Env has a higher glycan shield density than HIV Env that may contribute to poor or delayed nAb responses in SIVmac239-infected macaques. Passive transfer of a nAb protects macaques from repeated intravenous SIVmac239 challenge at serum titers comparable to those described for protection of humans against HIV infection. Our results provide structural insights for vaccine design and shed light on antibody-mediated protection in the SIV model.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos