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Why not? Motivations for entering a volunteer register for clinical trials during the COVID-19 pandemic.
Russo, Selena; Bani, Marco; Terraneo, Marco; Quaglia, Valeria; Nuvolati, Giampaolo; Cavaliere, Rebecca; Capici, Serena; Cazzaniga, Marina Elena; Strepparava, Maria Grazia.
Afiliación
  • Russo S; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
  • Bani M; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
  • Terraneo M; Department of Sociology, University of Milano-Bicocca, Milan, Italy.
  • Quaglia V; Department of Sociology, University of Milano-Bicocca, Milan, Italy.
  • Nuvolati G; Department of Sociology, University of Milano-Bicocca, Milan, Italy.
  • Cavaliere R; Royal College of Surgeons, University of Medicine and Health Sciences, Dublin, Ireland.
  • Capici S; Phase 1 Research Centre, ASST Monza, Monza, Italy.
  • Cazzaniga ME; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. marina.cazzaniga@unimib.it.
  • Strepparava MG; Phase 1 Research Centre, ASST Monza, Monza, Italy. marina.cazzaniga@unimib.it.
Eur J Clin Pharmacol ; 78(11): 1791-1800, 2022 Nov.
Article en En | MEDLINE | ID: mdl-36102931
ABSTRACT
BACKGROUNDS Healthy volunteers play a key role in clinical trials and it is crucial to develop recruitment strategies that capitalise on their motivations and maximise their participation. The COVID-19 pandemic has shown the importance of finding motivated healthy volunteers for the development of new vaccines. Public registers represent a promising way to promote the participation of healthy volunteers in the research field, but their adoption is still limited. The current study aimed to explore the motivations of healthy volunteers to enrol in an Italian public register for clinical trials during the COVID-19 pandemic and their attitude toward participating in a phase 1 COVID-19 vaccine clinical trial. The impacts of different enrolling interview modalities (in person, by phone, by mail) on motivation, understanding of information and trust in researchers were also investigated.

METHODS:

An online survey investigating experience with COVID-19, motivations to enrol, trust in researchers, political and healthcare authorities and pharmacological companies was presented to people applying as healthy volunteers in the public register for clinical trials at Phase 1 Unit Research Centre of ASST Monza, Italy, and considering to participate in a COVID-19 vaccine clinical trial. Data were collected in June 2021.

RESULTS:

Altruistic motivations were the main driver for enrolling in the public register, while self-interested motivations were secondary. No gender differences were found. As for enrolling modalities, no differences emerged between in-person and interviews for motivation to enrol, understanding of information and trust in researchers. Email modality led to significantly lower volunteers' satisfaction and understanding of information but similar trust in research.

CONCLUSIONS:

This study supports the validity of different interview modalities (in person and by phone) for the enrolment of healthy volunteers for clinical trials and highlights the positive role of public registers for the recruitment procedures.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans Idioma: En Revista: Eur J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans Idioma: En Revista: Eur J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Italia