Mammalian organ regeneration in spiny mice.
J Muscle Res Cell Motil
; 44(2): 39-52, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-36131170
ABSTRACT
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic options. Spiny mice (genus Acomys) are terrestrial mammals that regenerate severe skin wounds without fibrotic scars to evade predators. Recent studies have shown that spiny mice also regenerate acute ischemic and traumatic injuries to kidney, heart, spinal cord, and skeletal muscle. A common feature of this evolved wound healing response is a lack of formation of fibrotic scar tissue that degrades organ function, inhibits regeneration, and leads to organ failure. Complex tissue regeneration is an extremely rare property among mammalian species. In this article, we discuss the evidence that Acomys represents an emerging model organism that offers a unique opportunity for the biomedical community to investigate and clinically translate molecular mechanisms of scarless wound healing and regeneration of organ function in a mammalian species.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Cicatrización de Heridas
Límite:
Animals
Idioma:
En
Revista:
J Muscle Res Cell Motil
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos