Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts.
Nanoscale Adv
; 2(11): 5254-5262, 2020 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-36132036
ABSTRACT
Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Nanoscale Adv
Año:
2020
Tipo del documento:
Article