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Third Early "Booster" Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody Responses.
Ahmed-Belkacem, Abdelhakim; Redjoul, Rabah; Brillet, Rozenn; Ahnou, Nazim; Leclerc, Mathieu; López-Molina, Dennis Salomón; Soulier, Alexandre; Gourgeon, Aurélie; Rodriguez, Christophe; Maury, Sébastien; Pawlotsky, Jean-Michel; Fourati, Slim.
Afiliación
  • Ahmed-Belkacem A; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • Redjoul R; Haematology Department, Assistance Publique, Hôpitaux de Paris, Henri Mondor Hospital, 94000 Creteil, France.
  • Brillet R; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • Ahnou N; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • Leclerc M; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • López-Molina DS; Haematology Department, Assistance Publique, Hôpitaux de Paris, Henri Mondor Hospital, 94000 Creteil, France.
  • Soulier A; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • Gourgeon A; Department of Virology, Hôpital Henri Mondor, AP-HP, Université Paris-Est, 94000 Creteil, France.
  • Rodriguez C; Department of Virology, Hôpital Henri Mondor, AP-HP, Université Paris-Est, 94000 Creteil, France.
  • Maury S; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
  • Pawlotsky JM; Department of Virology, Hôpital Henri Mondor, AP-HP, Université Paris-Est, 94000 Creteil, France.
  • Fourati S; University Paris Est Créteil, INSERM U955, IMRB, 94010 Creteil, France.
Viruses ; 14(9)2022 08 30.
Article en En | MEDLINE | ID: mdl-36146735
Immunocompromised individuals generally fail to mount efficacious immune humoral responses following vaccination. The emergence of SARS-CoV-2 variants of concern has raised the question as to whether levels of anti-spike protein antibodies achieved after two or three doses of the vaccine efficiently protect against breakthrough infection in the context of immune suppression. We used a fluorescence-based neutralization assay to test the sensitivity of SARS-CoV-2 variants (ancestral variant, Beta, Delta, and Omicron BA.1) to the neutralizing response induced by vaccination in highly immunosuppressed allogeneic HSCT recipients, tested after two and three doses of the BNT162b2 vaccine. We show that neutralizing antibody responses to the Beta and Delta variants in most immunocompromised HSCT recipients increased after three vaccine doses up to values similar to those observed in twice-vaccinated healthy adults and were significantly lower against Omicron BA.1. Overall, neutralization titers correlated with the amount of anti-S-RBD antibodies measured by means of enzyme immunoassay, indicating that commercially available assays can be used to quantify the anti-S-RBD antibody response as a reliable surrogate marker of humoral immune protection in both immunocompetent and immunocompromised individuals. Our findings support the recommendation of additional early vaccine doses as a booster of humoral neutralizing activity against emerging variants, in HSCT immunocompromised patients. In the context of Omicron circulation, it further emphasizes the need for reinforcement of preventive measures including the administration of monoclonal antibodies in this high-risk population.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas Virales / Trasplante de Células Madre Hematopoyéticas / COVID-19 Límite: Adult / Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas Virales / Trasplante de Células Madre Hematopoyéticas / COVID-19 Límite: Adult / Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Francia