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Selective deuteration of bupropion slows epimerization and reduces metabolism.
Shi, Yuanyuan; Dinh, Jean; Pelletier, Robert; Raccor, Brianne; Yusuff, Naeem; Morgan, Adam J; Harbeson, Scott; Uttamsingh, Vinita; Totah, Rheem A.
Afiliación
  • Shi Y; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, United States.
  • Dinh J; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield S1 2BJ, United Kingdom.
  • Pelletier R; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, United States.
  • Raccor B; Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC 27506, United States.
  • Yusuff N; Concert Pharmaceuticals, Inc., 65 Hayden Ave. Suite 3000N, Lexington, MA 02421, United States.
  • Morgan AJ; Concert Pharmaceuticals, Inc., 65 Hayden Ave. Suite 3000N, Lexington, MA 02421, United States.
  • Harbeson S; Concert Pharmaceuticals, Inc., 65 Hayden Ave. Suite 3000N, Lexington, MA 02421, United States.
  • Uttamsingh V; Concert Pharmaceuticals, Inc., 65 Hayden Ave. Suite 3000N, Lexington, MA 02421, United States.
  • Totah RA; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, United States. Electronic address: rtotah@uw.edu.
Bioorg Med Chem Lett ; 76: 129009, 2022 11 15.
Article en En | MEDLINE | ID: mdl-36174836
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bupropión Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bupropión Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos