An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGF<i>ß</i> blockade therapy.

Pomponio, Robert; Tang, Qi; Mei, Anthony; Caron, Anne; Coulibaly, Bema; Theilhaber, Joachim; Rogers-Grazado, Maximilian; Sanicola-Nadel, Michele; Naimi, Souad; Olfati-Saber, Reza; Combeau, Cecile; Pollard, Jack; Lin, Tun Tun; Wang, Rui

An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFß blockade therapy.

Pomponio, Robert; Tang, Qi; Mei, Anthony; Caron, Anne; Coulibaly, Bema; Theilhaber, Joachim; Rogers-Grazado, Maximilian; Sanicola-Nadel, Michele; Naimi, Souad; Olfati-Saber, Reza; Combeau, Cecile; Pollard, Jack; Lin, Tun Tun; Wang, Rui.

Afiliación

Pomponio R; Sanofi Translational Medicine Early Development Cambridge, MA 02142, USA.
Tang Q; Sanofi Artificial Intelligence and Deep Analytics Data and Data Sciences, Cambridge, MA 02142, USA.
Mei A; Sanofi Artificial Intelligence and Deep Analytics Data and Data Sciences, Cambridge, MA 02142, USA.
Caron A; Sanofi Translational Science, Vitry sur Seine 94403, France.
Coulibaly B; Sanofi Translational Science, Vitry sur Seine 94403, France.
Theilhaber J; Sanofi Precision Oncology Cambridge, MA 02142, USA.
Rogers-Grazado M; Sanofi Precision Oncology Cambridge, MA 02142, USA.
Sanicola-Nadel M; Sanofi Oncology Early Development Cambridge, MA 02142, USA.
Naimi S; Sanofi Translational Science, Vitry sur Seine 94403, France.
Olfati-Saber R; Sanofi Artificial Intelligence and Deep Analytics Data and Data Sciences, Cambridge, MA 02142, USA.
Combeau C; Sanofi Translational Medicine Early Development Cambridge, MA 02142, USA.
Pollard J; Sanofi Precision Oncology Cambridge, MA 02142, USA.
Lin TT; Sanofi Oncology Early Development Cambridge, MA 02142, USA.
Wang R; Sanofi Translational Medicine Early Development Cambridge, MA 02142, USA.

Acta Pharm Sin B ; 12(9): 3594-3601, 2022 Sep.

Article en En | MEDLINE | ID: mdl-36176910

Palabras clave

Artificial intelligence; Digital pathology; Machine learning; Predictive biomarker; T cell infiltration; TGFß; Transcriptomic profiling; Tumor topography

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Acta Pharm Sin B Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google