Fecal Calprotectin and Quality of Life Questionnaires Are Responsive to Change in Pouch Disease Activity After Antibiotic Therapy: Results From a Prospective Clinical Trial.
Am J Gastroenterol
; 118(2): 367-370, 2023 02 01.
Article
en En
| MEDLINE
| ID: mdl-36191275
ABSTRACT
INTRODUCTION:
Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity in patients with a J-pouch is unknown.METHODS:
Patients with acute pouchitis were prospectively treated with a 2-week course of antibiotics. The full Pouchitis Disease Activity Index, FC, and QoL questionnaires were measured at baseline and after antibiotic therapy.RESULTS:
Twenty patients were prospectively enrolled. After 2 weeks of antibiotic treatment, the Pouchitis Disease Activity Index decreased from a median of 9 to 5 ( P = 0.007). FC decreased from a median of 661 ug/g to 294 ug/g ( P = 0.02), and QoL questionnaires improved significantly.DISCUSSION:
FC and QoL questionnaires reflect real-time changes in inflammatory pouch activity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Colitis Ulcerosa
/
Reservoritis
Límite:
Humans
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Israel