Your browser doesn't support javascript.
loading
Detection and monitoring of HBV-related hepatocellular carcinoma from plasma cfDNA fragmentation profiles.
Sun, Xinfeng; Feng, Wenxing; Cui, Pin; Ruan, Ruyun; Ma, Wenfeng; Han, Zhiyi; Sun, Jialing; Pan, Yuanke; Zhu, Jinxin; Zhong, Xin; Li, Jing; Ma, Mengqing; Hu, Rui; Lv, Minling; Huang, Qi; Zhang, Wei; Feng, Mingji; Zhuang, Xintao; Huang, Bingding; Zhou, Xiaozhou.
Afiliación
  • Sun X; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Feng W; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Cui P; Shenzhen Rapha Biotechnology Incorporate, Shenzhen 518118, China.
  • Ruan R; College of Big Data and Internet, Shenzhen Technology University, Shenzhen 518118, China.
  • Ma W; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Han Z; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Sun J; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Pan Y; College of Big Data and Internet, Shenzhen Technology University, Shenzhen 518118, China.
  • Zhu J; College of Big Data and Internet, Shenzhen Technology University, Shenzhen 518118, China.
  • Zhong X; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Li J; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Ma M; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Hu R; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Lv M; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Huang Q; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Zhang W; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
  • Feng M; Shenzhen Rapha Biotechnology Incorporate, Shenzhen 518118, China.
  • Zhuang X; Shenzhen Rapha Biotechnology Incorporate, Shenzhen 518118, China.
  • Huang B; College of Big Data and Internet, Shenzhen Technology University, Shenzhen 518118, China. Electronic address: huangbingding@sztu.edu.cn.
  • Zhou X; Department of Liver Disease, the fourth Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen 518033, China; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China. Electronic address: zxz1006@gzucm.edu.cn.
Genomics ; 114(6): 110502, 2022 11.
Article en En | MEDLINE | ID: mdl-36220554
ABSTRACT
Most hepatocellular carcinomas (HCCs) are associated with hepatitis B virus infection (HBV) in China. Early detection of HCC can significantly improve prognosis but is not yet fully clinically feasible. This study aims to develop methods for detecting HCC and studying the carcinogenesis of HBV using plasma cell-free DNA (cfDNA) whole-genome sequencing (WGS) data. Low coverage WGS was performed for 452 participants, including healthy individuals, hepatitis B patients, cirrhosis patients, and HCC patients. Then the sequencing data were processed using various machine learning models based on cfDNA fragmentation profiles for cancer detection. Our best model achieved a sensitivity of 87.10% and a specificity of 88.37%, and it showed an increased sensitivity with higher BCLC stages of HCC. Overall, this study proves the potential of a non-invasive assay based on cfDNA fragmentation profiles for the detection and prognosis of HCC and provides preliminary data on the carcinogenic mechanism of HBV.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article País de afiliación: China