Requirement for 24(S),25-epoxycholesterol for the viability of cultured fibroblasts.
Exp Cell Res
; 171(2): 492-7, 1987 Aug.
Article
en En
| MEDLINE
| ID: mdl-3622642
ABSTRACT
Previous studies on a somatic cell mutant auxotrophic for mevalonate (Mev-1) have shown that these cells rapidly lose viability when deprived of mevalonic acid in culture medium supplemented with serum cholesterol. Testing of all known end products of mevalonate metabolism in cultured mammalian cells has been conducted to determine the basis for this mevalonate requirement. It has been found that the recently discovered mevalonate metabolite 24(S),25-epoxycholesterol produces a partial restoration of viability of Mev-1 cells starved for mevalonate, whereas other structurally similar oxysterols do not. It appears that 24(S),25-epoxycholesterol has a specific, vital cellular function in CHO-K1 cells.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Colesterol
/
Fibroblastos
Límite:
Animals
Idioma:
En
Revista:
Exp Cell Res
Año:
1987
Tipo del documento:
Article