Formation of a cyclic imide in aspartyl or asparaginyl glycyl peptides induced by heating in the dry state.
Int J Pept Protein Res
; 29(6): 728-33, 1987 Jun.
Article
en En
| MEDLINE
| ID: mdl-3623803
A common product was identified by HPLC from the heating of, alpha and beta isomers of, aspartyl glycine in the dry state. Fast atom-bombardment (FAB) mass spectrometry and Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) showed that the product is a cyclic imide. Cyclic imide formation also was shown to occur with the tripeptides Gly-Asp-Gly and Gly-Asn-Gly. The cyclization of aspartyl peptides depends upon protonation of the beta-carboxyl group and can be promoted by acidification or by heating the NH4+ salt in the dry state.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Péptidos Cíclicos
/
Asparagina
/
Ácido Aspártico
Idioma:
En
Revista:
Int J Pept Protein Res
Año:
1987
Tipo del documento:
Article