Photocatalytic Incorporation of an Oxime Ether Functional Group at Inert C(sp3)-H Bonds via HAT.

Herein, we describe a photocatalytic method for the direct incorporation of an oxime functional group at inert C(sp3)-H bonds of ethers, amides, alcohols, amines, and alkanes via HAT with photoexcited eosin Y under mild conditions using air and a blue LED. Many useful functional groups are tolerated in this process, and the reaction is scalable. A series of mechanistic studies were carried out to support the radical pathway proposed for the process.