Intravenous injection of a novel viral immunotherapy encoding human interleukin-7 in nonhuman primates is safe and increases absolute lymphocyte count.

Coupet, Charles-Antoine; Dubois, Clarisse; Evlachev, Alexeï; Kehrer, Nadine; Baldazza, Marie; Hofman, Sam; Vierboom, Michel; Martin, Perrine; Inchauspe, Geneviève

Coupet, Charles-Antoine; Dubois, Clarisse; Evlachev, Alexeï; Kehrer, Nadine; Baldazza, Marie; Hofman, Sam; Vierboom, Michel; Martin, Perrine; Inchauspe, Geneviève.

Afiliación

Coupet CA; Infectious Diseases Department, Transgene SA, Lyon, France.
Dubois C; Infectious Diseases Department, Transgene SA, Lyon, France.
Evlachev A; Infectious Diseases Department, Transgene SA, Lyon, France.
Kehrer N; Infectious Diseases Department, Transgene SA, Lyon, France.
Baldazza M; Infectious Diseases Department, Transgene SA, Lyon, France.
Hofman S; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Vierboom M; Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Martin P; Infectious Diseases Department, Transgene SA, Lyon, France.
Inchauspe G; Infectious Diseases Department, Transgene SA, Lyon, France.

Hum Vaccin Immunother ; 18(6): 2133914, 2022 11 30.

Article en En | MEDLINE | ID: mdl-36315906

Asunto(s)

Interleucina-7; Virus Vaccinia; Humanos; Ratones; Animales; Interleucina-7/genética; Inmunoterapia; Recuento de Linfocitos; Macaca fascicularis

Palabras clave

Immunotherapy; Modified Vaccinia virus Ankara; immune activation; interleukin-7; nonhuman primates; pharmacokinetics; virotherapy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus Vaccinia / Interleucina-7 Límite: Animals / Humans Idioma: En Revista: Hum Vaccin Immunother Año: 2022 Tipo del documento: Article País de afiliación: Francia

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