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The Design of 3D-Printed Polylactic Acid-Bioglass Composite Scaffold: A Potential Implant Material for Bone Tissue Engineering.
Sultan, Sahar; Thomas, Nebu; Varghese, Mekha; Dalvi, Yogesh; Joy, Shilpa; Hall, Stephen; Mathew, Aji P.
Afiliación
  • Sultan S; Department of Materials and Environmental Chemistry, Stockholm University, 114 19 Stockholm, Sweden.
  • Thomas N; Department of Periodontology, Pushpagiri College of Dental Sciences, Kerala University of Health Sciences [KUHS], Medicity, Perumthuruthy, Tiruvalla 689107, Kerala, India.
  • Varghese M; Department of Periodontology, Pushpagiri College of Dental Sciences, Kerala University of Health Sciences [KUHS], Medicity, Perumthuruthy, Tiruvalla 689107, Kerala, India.
  • Dalvi Y; Pushpagiri Research Center, Pushpagiri Institute of Medical Sciences and Research Centre, Kerala University of Health Sciences [KUHS], Thiruvalla 689101, Kerala, India.
  • Joy S; Department of Biotechnology, Sri Shakthi Institute of Engineering and Technology, Coimbatore 641062, Tamil Nadu, India.
  • Hall S; Division of Solid Mechanics, Lund University, 221 00 Lund, Sweden.
  • Mathew AP; Lund Institute of Advanced Neutron and X-ray Science, 223 70 Lund, Sweden.
Molecules ; 27(21)2022 Oct 25.
Article en En | MEDLINE | ID: mdl-36364053
Bio-based and patient-specific three-dimensional (3D) scaffolds can present next generation strategies for bone tissue engineering (BTE) to treat critical bone size defects. In the present study, a composite filament of poly lactic acid (PLA) and 45S5 bioglass (BG) were used to 3D print scaffolds intended for bone tissue regeneration. The thermally induced phase separation (TIPS) technique was used to produce composite spheres that were extruded into a continuous filament to 3D print a variety of composite scaffolds. These scaffolds were analyzed for their macro- and microstructures, mechanical properties, in vitro cytotoxicity and in vivo biocompatibility. The results show that the BG particles were homogeneously distributed within the PLA matrix and contributed to an 80% increase in the mechanical strength of the scaffolds. The in vitro cytotoxicity analysis of PLA-BG scaffolds using L929 mouse fibroblast cells confirmed their biocompatibility. During the in vivo studies, the population of the cells showed an elevated level of macrophages and active fibroblasts that are involved in collagen extracellular matrix synthesis. This study demonstrates successful processing of PLA-BG 3D-printed composite scaffolds and their potential as an implant material with a tunable pore structure and mechanical properties for regenerative bone tissue engineering.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Andamios del Tejido Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Andamios del Tejido Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Suecia